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SB242235

Product Name
SB242235
CAS No.
193746-75-7
Chemical Name
SB242235
Synonyms
CS-668;SB242235;SB242235 ≥95%;SB-242235; SB242235;inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine;4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine;Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
CBNumber
CB12621150
Molecular Formula
C19H20FN5O
Formula Weight
353.39
MOL File
193746-75-7.mol
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SB242235 Property

Boiling point:
568.4±60.0 °C(Predicted)
Density 
1.34
storage temp. 
2-8°C(protect from light)
solubility 
DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml
form 
Powder
pka
9.91±0.10(Predicted)
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
474182
Product name
SB 242235
Packaging
100mg
Price
$1848
Updated
2021/12/16
Biorbyt Ltd
Product number
orb180841
Product name
SB242235
Purity
>98%
Packaging
1000mg
Price
$2395.3
Updated
2021/12/16
Matrix Scientific
Product number
132624
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity
97%
Packaging
5g
Price
$3960
Updated
2021/12/16
AK Scientific
Product number
3254AH
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Packaging
5g
Price
$5396
Updated
2021/12/16
Matrix Scientific
Product number
132624
Product name
4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl)-2-methoxypyrimidine
Purity
97%
Packaging
10g
Price
$6480
Updated
2021/12/16
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SB242235 Chemical Properties,Usage,Production

Biological Activity

SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 μM in human chondrocytes.

in vitro

SB 242235 (0-10 μM) dose-dependently inhibits the activation of MAPKAP K2 with an IC 50 of 1.0 μM in human chondrocytes stimulated with IL-1β.
SB 242235 inhibits intracellular p38 activity, MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate.

Western Blot Analysis

< td class="col2"> 15 minutes
Cell Line: Human chondrocytes
Concentration: 0 μM, 0.01 μM, 0.1 μM, 1 μM, 10 μM
Incubation Time:
Result: Dose-dependently inhibited the activation of MAPKAP K2 with an IC 50 of 1.0 μM.

target

IC50: 1.0 μM (p38 MAPK, primary human chondrocytes)

SB242235 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB242235 Suppliers

China 51 France 1 India 1 United Kingdom 2 United States 10 Global 65
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58

193746-75-7, SB242235Related Search:

SB 743921 Pracinostat SB 225002 SB216763 Sb-742457 MMP-2/MMP-9 INHIBITOR IV SB 242084 (hydrochloride) SB 415286 SB 202190 SB 431542 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime SB 269970 HYDROCHLORIDE SB1317 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 4'-CHLORO-3-METHOXYCINNAMANILIDE SB-705498 SB 203580 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

  • SB-242235; SB242235
  • CS-668
  • SB242235
  • 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxypyrimidine
  • 4-(4-(4-Fluorophenyl)-1-(piperidin-4-yl)-1H-iMidazol-5-yl)-2-MethoxypyriMidine
  • SB242235 ≥95%
  • Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-
  • inhibit,SB 242235,Autophagy,Inhibitor,p38 MAPK
  • 193746-75-7